Outcomes of endoscopic retrograde cholangiopancreatography: a series from a provincial New Zealand hospital.

BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) is an essential tool in the management of pancreaticobiliary pathology. It is technically demanding and has the potential to cause significant morbidity and mortality. Several trials have identified small centres and lower hospital volume as risk factors for lower success rates and higher complication rates. Taranaki Base Hospital (TBH) is a provincial hospital with a catchment of 100 000, providing its population with an on-site ERCP service. Transporting patients to the nearest tertiary centre would incur significant costs to both the patient and district health board. AIMS: To determine the outcomes of performing ERCP at TBH and compare these with published figures. To determine if it is a safe and effective option for patients in this region. METHODS: An ambi-directional study of all ERCP procedures at TBH between January 2011 and December 2015 was conducted. Patient demographics, procedure indication and procedural details were captured via ProVation® MD and endoscopist's notes. Complications were identified through patient's notes and recorded if occurring within 30 days of the procedure. All complications were graded mild, moderate or severe based on a grading system described by Cotton et al. RESULTS: A total of 445 procedures were performed. Bile duct cannulation rate was 92.3% and therapeutic success rate was 89.9%. Complications occurred in 8.99% of patients and ERCP-specific mortality was 0.22%. Haemorrhage occurred in 1.35% of patients, pancreatitis in 5.2% and perforation in 0.45%. Success and complication rates are similar to other published studies. CONCLUSION: ERCP can be safely and successfully performed in a provincial centre.

The incidence and risk factors for lower limb skin graft failure.

Lower limb skin grafts are thought to have higher failure rates than skin grafts in other sites of the body. Currently, there is a paucity of literature on specific factors associated with lower limb skin graft failure. We present a series of 70 lower limb skin grafts in 50 patients with outcomes at 6 weeks. One-third of lower limb skin grafts went on to fail with increased BMI, peripheral vascular disease, and immunosuppressant medication use identified as significant risk factors.

Interhospital transfer of acute general surgical patients in the Taranaki region of New Zealand.

AIM: This study investigated the transfer of acute general surgical patients from HPH to TBH in order to evaluate Interhospital transfer time in a rural New Zealand setting. It specifically investigates the prioritisation and time to transfer of unwell patients who required ICU/HDU admission following transfer. METHOD: 9 months case-control retrospective study based on review of ambulance' "patient transfer sheets" and patients' medical records. Ambulance transfers of General Surgical emergencies were divided into two groups and analysed with group 1 admitted to ICU (ICU group) versus those admitted to the wards (non-ICU group). RESULTS: The majority of patients in the non-ICU group (34 patients, 77%) were managed conservatively while 8 patients (18%) underwent operative intervention. Four patients (24%) in the ICU group had surgery while 7 patients (41%) needed specialist investigations such as gastroscopy (n=5), ERCP (n=1) or angiography (n=1). One patient in each group died during their admission at TBH. CONCLUSIONS: There was no statistically significant difference in ambulance transfer times between the ICU and non-ICU groups (138 versus 124 minutes respectively), with the main determinant being the "ambulance response time" which could have been shortened by better identification of acute general surgical patients who ultimately required ICU/HDU care following transfer. The development of local protocols and checklists ensuring necessary communication between hospital and ambulance staff may allow better triage and prioritisation of transfer and lead to shorter transfer times for more unwell patients.

Probing the urinary proteome of severe acute pancreatitis.

BACKGROUND: Proteinuria is a characteristic feature of severe acute pancreatitis (SAP) that may allow unique insights into AP pathophysiology. This study used a proteomic approach to differentiate the abundant urinary proteins in AP patients. MATERIALS AND METHODS: Urine samples were prospectively collected from 4 groups (5 SAP, 10 mild gallstone AP, 7 mild alcohol AP, 7 controls). Reverse-phase high-performance liquid chromatography (RP-HPLC) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (LC MALDI) were used to identify urinary proteins and determine any differences between the groups. RESULTS: There were 17 RP-HPLC major peaks in SAP groups of significantly greater absorbance magnitude than the corresponding ones in mild and control groups. Various mass spectrometry methods were used to identify 21 different parent proteins from these SAP peaks. They included fibrinogen, serum amyloid A, insulin and calcitonin gene-related peptides. There were no identifiable protein peaks at the corresponding elution times in the mild pancreatitis and controls samples. DISCUSSION: Proteomic techniques offer a unique unexplored window into AP pathophysiology. The utility of these proteins as markers of pancreatitis severity now need to be further investigated and the identification extended to the full urinary proteome as technology permits.